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KMID : 1037120190370010085
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The World Journal of Men′s Health
2019 Volume.37 No. 1 p.85 ~ p.92
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Choroidal Thickness Analysis in Patients with Erectile Dysfunction
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Kim Yong-Kyu
Lee Jang-Hoon
Park Sung-Pyo
Yang Dae-Yul
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Abstract
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Purpose: To investigate the morphological features of choroidal vasculature in patients with erectile dysfunction (ED) by analyzing choroidal thickness using optical coherence tomography.
Materials and Methods: We enrolled 39 patients with ED and 19 controls. ED was defined as an erectile function domain score <26 on the International Index of Erectile Function (IIEF) questionnaire. Small-choroidal-vessel-layer (SCVL) thickness was calculated by subtracting large-choroidal-vessel-layer (which corresponded to Haller’s layer) thickness from total choroidal thickness. Choroidal thickness was compared between the ED and control groups.
Results: SCVL thickness was lesser in the ED group than in the control group (control, 69.8±24.3 μm vs. ED, 55.1±19.9 μm; p=0.017). Among patients without diabetes, the ED group showed significantly lesser SCVL thickness than did the control group (control, 77.1±22.7 μm vs. ED, 56.5±20.9 μm; p=0.021). However, among patients with diabetes, choroidal thickness showed no significant intergroup difference. Multiple linear regression analysis revealed that spherical equivalent (standardized coefficient β=0.294; p=0.019) and the IIEF erectile function score (standardized coefficient β=0.315; p=0.012) were significantly associated with SCVL thickness.
Conclusions: SCVL thickness, including the choriocapillaris layer and medium-sized choroidal vascular layer, decreased in proportion to ED severity, suggesting that microvascular changes in choroidal vessels may occur before specific ocular diseases in patients with ED.
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KEYWORD
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Choroid, Erectile dysfunction, Tomography, optical coherence
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